Evaluation of the Anti-Viral Activity of Human Recombinant Interferon Lambda-1 against SARS-CoV-2

Author:

Madonov P. G.,Svyatchenko V. A.,Legostaev S. S.,Kikhtenko N. A.,Kotlyarova A. A.,Oleinik L. A.,Baikalov G. I.

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference7 articles.

1. Kirilyuk IA, Svyatchenko VA, Morozov DA, Kazachinskaya EI, Kiselev NN, Bakunova SM, Voinov MA, Loktev VB, Grigoryev IA. In vitro cytotoxicity of nitroxyl radicals with respect to tumor and diploid human cells and estimation of their antiviral activity. Antibiotiki Khimioterapiya. 2012;57(1-2):3-12. Russian.

2. Busnadiego I, Fernbach S, Pohl MO, Karakus U, Huber M, Trkola A, Stertz S, Hale BG. Antiviral activity of type I, II, and III interferons counterbalances ACE2 inducibility and restricts SARS-CoV-2. mBio. 2020;11(5):e01928-20. doi: https://doi.org/10.1128/mBio.01928-20

3. Dinnon KH 3rd, Leist SR, Schäfer A, Edwards CE, Martinez DR, Montgomery SA, West A, Yount BL Jr, Hou YJ, Adams LE, Gully KL, Brown AJ, Huang E, Bryant MD, Choong IC, Glenn JS, Gralinski LE, Sheahan TP, Baric RS. A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures. Nature. 2020;586:560-566. doi: https://doi.org/10.1038/s41586-020-2708-8

4. O’Brien TR, Thomas DL, Jackson SS, Prokunina-Olsson L, Donnelly RP, Hartmann R. Weak Induction of interferon expression by severe acute respiratory syndrome coronavirus 2 supports clinical trials of interferon-λ to treat early coronavirus disease 2019. Clin. Infect. Dis. 2020;71(6):1410-1412. doi: https://doi.org/10.1093/cid/ciaa453

5. Peignier A, Parker D. Pseudomonas aeruginosa can degrade interferon λ, thereby repressing the antiviral response of bronchial epithelial cells. J. Interferon Cytokine Res. 2020;40(8):429-431. doi: https://doi.org/10.1089/jir.2020.0057

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