Transferrin binding of bone marrow cells and metabolic activity of erythrocytes after 5 Gy irradiation

Author:

Sancho Pilar1,Cuenllas Elvira2,Gaitan Soledad2,Tejero Concepción2

Affiliation:

1. Departmento de Bioquímica y Biología Molecular, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain

2. Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Spain

Abstract

The effect of total body irradiation (5 Gy) on functional mouse erythroid lineage has been studied. The transferrin binding capacity by bone marrow cells and the activity of glycolytic regulatory enzymes and intracellular levels of 2,3 bisphosphoglycerate in peripheral blood erythrocytes have been determined. Results obtained along one year post-irradiation period suggest a complete recovery in the erythroid cell lineage with respect to the biological endpoints investigated.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference22 articles.

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2. Testa, N. G., Hendry, J. H. & Molineaux, G. (1985)Anticancer Res. 5:101?110.

3. Gaitan, S., Cuenllas, E., Sancho, P., Bueren, J. and Tejero, C. (1991) 9th International Congress of Radiation Research. Toronto, 7?12 July 1991.

4. Taetle, R. (1990)Exp. Hematol. 18:360?365.

5. Mendieta, J., Herraez, A., Sancho, P. and Luque, J. (1989)Biosci. Rep. 9: 541?548.

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