Early life seizures in female rats lead to anxiety-related behavior and abnormal social behavior characterized by reduced motivation to novelty and deficit in social discrimination

Author:

Castelhano Adelisandra Silva Santos,Ramos Fabiane Ochai,Scorza Fulvio Alexandre,Cysneiros Roberta Monterazzo

Publisher

Springer Science and Business Media LLC

Subject

Biological Psychiatry,Psychiatry and Mental health,Neurology (clinical),Neurology

Reference31 articles.

1. Andersen ML, Tufik S (2010) Animal models as tools in ethical biomedical research. Associação Fundo de Incentivo à Psicofarmacologia-Universidade Federal de São Paulo, São Paulo

2. Briggs SW, Galanopoulou AS (2011) Altered GABA signaling in early life epilepsies. Neural Plasticity. doi: 10.1155/2011/527605

3. Castelhano ASS, Cassane GST, Scorza FA, Cysneiros RM (2013) Altered anxiety-related and abnormal social behaviors in rats exposed to early life seizures. Front Behav Neurosci 7(36):1–8. doi: 10.3389/fnbeh.2013.00036

4. Chao HT, Chen HM, Samaco RC, Xue MS, Chahrour M, Yoo J, Neul JL, Gong SC, Lu HC, Heintz N, Ekker M, Rubenstein JLR, Noebels JL, Rosenmund C, Zoghbi HY (2010) Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature 468(7321):263–269. doi: 10.1038/nature09582

5. Cornejo BJ, Mesches MH, Coultrap S, Browning MD, Benke TA (2007) Single episode of neonatal seizures permanently alters glutamatergic synapses. Ann Neurol 61(5):411–426. doi: 10.1002/ana.21071

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