MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats

Author:

Bessho Tomoko,Takashina Ken,Eguchi Junichi,Komatsu Teiko,Saito Ken-Ichi

Publisher

Springer Science and Business Media LLC

Subject

Biological Psychiatry,Psychiatry and Mental health,Neurology (clinical),Neurology

Reference16 articles.

1. Bartus RT (2000) On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp Neurol 163:495–529

2. Bessho T, Takashina K, Tabata R, Oshima C, Chaki H, Yamabe H, Egawa M, Tobe A, Saito K-I (1996) Effects of the novel high affinity choline uptake enhancer 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro [2,3-b] quinolin-4-yl) acetoamide on deficits of water maze learning in rats. Arzneimittelforschung 46:369–373

3. Ferguson SM, Blakely RD (2004) The choline transporter resurfaces: new roles for synaptic vesicles. Mol Interv 4:22–37

4. Ferguson SM, Savchenko V, Apparsundaram S, Zwick M, Wright J, Heilman C, Yi H, Levey AI, Blakely RD (2003) Vesicular localization and activity-dependent trafficking of presynaptic choline transporters. J Neurosci 23:9697–9709

5. Fisher A, Mantione CR, Abraham DJ, Hanin I (1982) Long-term central cholinergic hypofunction induced in mice by ethylcholine aziridinium ion (AF64A) in vivo J Pharmcol Exp Ther 222:140–145

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