Author:
Lahonian Mansour,Khedri Sepideh,Aminian Saman,Ranjbari Leyla,Ardalan Aram
Abstract
AbstractIn this study, the capture efficiency (CE) of magnetic carrier particles at the region of interest (ROI) in a micro-vessel was investigated. A nonuniform magnetic field produced by a Nd-Fe-B magnet was applied to capture the carrier particles at the ROI. The particle–particle and red blood cell (RBC)–carrier particle interactions were taken into account. Other parameters including carrier particle diameter, magnetic force, and non-Newtonian behavior of blood were also considered. The finite element method was used to solve the governing equations. Four cases were considered: (1) Newtonian without interaction forces, (2) Newtonian with interaction forces, (3) non-Newtonian without interaction forces, and (4) non-Newtonian with interaction forces. The results showed that for a particle diameter of 2000 nm, the CE values for the case without interaction force and with interaction force were 70% and 53%, respectively. It was found that by considering the particle–particle and RBC–carrier particle interactions for all magnet–vessel distances, the CE of carrier particles decreased, on average, by nearly 19%. At a magnet–vessel distance of 2.5 cm ($$d=2.5\,\mathrm{cm}),$$
d
=
2.5
cm
)
,
it was seen that the CE values for case 2 and case 3 were nearly 70% and 45%, representing the maximum and minimum CE values, respectively.
Publisher
Springer Science and Business Media LLC
Subject
Mechanical Engineering,Mechanics of Materials,Computational Mechanics
Reference37 articles.
1. Aggarwal A, Chhajer P, Maheshwari S (2012) Magnetic drug delivery in therapeutics. Int J Pharm Sci Res 3:4670
2. Ahmad M, Minhas MU, Sohail M, Faisal M (2013) Comprehensive review on magnetic drug delivery systems: a novel approach for drug targeting. J Pharm Altern Med 2:13–21
3. Ardalan A, Aminian S, Seyfaee A, Gharehkhani S (2021) Effects of geometrical parameters on the capture efficiency of nanoparticles under the influence of the magnetic field in a stenosed vessel. Powder Technol. https://doi.org/10.1016/j.powtec.2020.11.023
4. Avval ZM, Malekpour L, Raeisi F, Babapoor A, Mousavi SM, Hashemi SA, Salari M (2020) Introduction of magnetic and supermagnetic nanoparticles in new approach of targeting drug delivery and cancer therapy application. Drug Metab Rev 52:157–184. https://doi.org/10.1080/03602532.2019.1697282
5. Banerjee MK, Datta A, Ganguly R (2010) Magnetic drug targeting in partly occluded blood vessels using magnetic microspheres. J Nanotechnol Eng Med. https://doi.org/10.1115/1.4002418
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献