First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase-Reference-Cited by-同舟云学术

First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase

Published:2019-01-02 Issue:2 Volume:33 Page:295-305
ISSN:0920-654X
Container-title:Journal of Computer-Aided Molecular Design
language:en
Short-container-title:J Comput Aided Mol Des

Author:

Spyrakis Francesca^ORCID,Bellio Pierangelo,Quotadamo Antonio,Linciano Pasquale,Benedetti Paolo,D’Arrigo Giulia,Baroni Massimo,Cendron Laura,Celenza Giuseppe,Tondi Donatella^ORCID

Funder

Fondo di Ricerca di Ateneo

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry,Computer Science Applications,Drug Discovery

Link

http://link.springer.com/content/pdf/10.1007/s10822-018-0182-2.pdf

Reference44 articles.

1. Tondi D, Cross S, Venturelli A et al (2016) Decoding the structural basis for carbapenem hydrolysis by class A β-lactamases: fishing for a pharmacophore. Curr Drug Targets 17:983–1005. https://doi.org/10.2174/1389450116666151001104448

2. Cantón R, Akóva M, Carmeli Y et al (2012) Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect 18:413–431. https://doi.org/10.1111/j.1469-0691.2012.03821.x

3. Naas T, Poirel L, Nordmann P (2008) Minor extended-spectrum beta-lactamases. Clin Microbiol Infect. https://doi.org/10.1111/j.1469-0691.2007.01861.x

4. Weldhagen GF (2006) Genetic stability of class 1 integron-borne blaGES-type genes under short-term in vitro antibiotic stress. Int J Antimicrob Agents 28:481–483. https://doi.org/10.1016/j.ijantimicag.2006.08.012

5. Smith CA, Nossoni Z, Toth M et al (2016) Role of the conserved disulfide bridge in class A carbapenemases. J Biol Chem 291:22196–22206. https://doi.org/10.1074/jbc.M116.749648

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3. Targeting the Class A Carbapenemase GES-5 via Virtual Screening;Biomolecules;2020-02-14

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