C1r serine proteinase of human complement: A case of intramolecular autolytic activation-Reference-Cited by-同舟云学术

C1r serine proteinase of human complement: A case of intramolecular autolytic activation

Published:1985-01-01 Issue:10-11 Volume:5 Page:831-837
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Arlaud Gérard J.¹,Colomb Maurice G.¹,Villiers Christian L.¹

Affiliation:

1. Laboratoire d'Immunochimie, Centre d'Etudes Nucléaires de Grenoble, DRF/L Bio/Immunochimie, C.E.N. Grenoble 85X, 38041 Grenoble Cedex, France

Abstract

This paper presents a short review of our contribution to the knowledge of the structure and function of human Clr, the activation unit of C1, the first component of the classical pathway of complement. On the basis of the domain structure of Clr, a model accounting for its autolytic activation mechanism is proposed. We suggest that this represents the basic mechanism of C1 function.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/5/10-11/831/471933/bsr0050831.pdf

Reference23 articles.

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