Enzyme regulation by biological disulfides-Reference-Cited by-同舟云学术

Enzyme regulation by biological disulfides

Published:1989-10-01 Issue:5 Volume:9 Page:593-604
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Ondarza Raul N.¹

Affiliation:

1. Biochemistry Department, Faculty of Medicine, Universidad Nacional Autonoma de Mexico, General Director, The Southeast Ecological Res. Ctr., San Cristobal de Las Casas, Chiapas, 29290 Mexico

Abstract

More than a dozen enzymes have been found to be activated or inhibited in vitro by disulfide-exchange between the protein and small-molecule disulfides. Accordingly, thiol/disulfide ratio changes in vivo may be of great importance in the regulation of cellular metabolism. An awareness of this regulatory mechanism in both host cells and parasites, coupled with information on the presence or absence of key enzymes, may lead to rational drug design against certain diseases involving thiol intermediates, including trypanosomiasis.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/9/5/593/473405/bsr0090593.pdf

Reference60 articles.

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