Down-regulation of MDR1 by Ad-DKK3 via Akt/NFκB pathways augments the anti-tumor effect of temozolomide in glioblastoma cells and a murine xenograft model

Author:

Fujihara ToshitakaORCID,Mizobuchi Yoshifumi,Nakajima Kohei,Kageji Teruyoshi,Matsuzaki Kazuhito,Kitazato Keiko T.,Otsuka Ryotaro,Hara Keijiro,Mure Hideo,Okazaki Toshiyuki,Kuwayama Kazuyuki,Nagahiro Shinji,Takagi Yasushi

Funder

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Neurology (clinical),Neurology,Oncology

Reference31 articles.

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2. Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason W, Mariani L, Bromberg JE, Hau P, Mirimanoff RO, Cairncross JG, Janzer RC, Stupp R (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. New Eng J Med 352(10):997–1003. https://doi.org/10.1056/NEJMoa043331

3. Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA, Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa S, Eisenhauer E, Gorlia T, Weller M, Lacombe D, Cairncross JG, Mirimanoff RO, European Organisation for Research, Treatment of Cancer Brain Tumour, Radiation Oncology Groups, National Cancer Institute of Canada Clinical Trials Group (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10(5):459–466. https://doi.org/10.1016/S1470-2045(09)70025-70027

4. Chin JE, Soffir R, Noonan KE, Choi K, Roninson IB (1989) Structure and expression of the human MDR (P-glycoprotein) gene family. Mol Cell Biol 9(9):3808–3820

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