Do animal models of brain tumors replicate human peritumoral edema? a systematic literature search
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Published:2023-02
Issue:3
Volume:161
Page:451-467
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ISSN:0167-594X
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Container-title:Journal of Neuro-Oncology
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language:en
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Short-container-title:J Neurooncol
Author:
Schramm Moritz W. J.,Currie Stuart,Lee Ming-te,Livermore Laurent J.,Solanki Sandeep P.,Mathew Ryan K.,Wurdak Heiko,Lorger Mihaela,Twelves Chris,Short Susan C.,Chakrabarty Aruna,Chumas Paul
Abstract
Abstract
Introduction
Brain tumors cause morbidity and mortality in part through peritumoral brain edema. The current main treatment for peritumoral brain edema are corticosteroids. Due to the increased recognition of their side-effect profile, there is growing interest in finding alternatives to steroids but there is little formal study of animal models of peritumoral brain edema. This study aims to summarize the available literature.
Methods
A systematic search was undertaken of 5 literature databases (Medline, Embase, CINAHL, PubMed and the Cochrane Library). The generic strategy was to search for various terms associated with “brain tumors”, “brain edema” and “animal models”.
Results
We identified 603 reports, of which 112 were identified as relevant for full text analysis that studied 114 peritumoral brain edema animal models. We found significant heterogeneity in the species and strain of tumor-bearing animals, tumor implantation method and edema assessment. Most models did not produce appreciable brain edema and did not test for observable manifestations thereof.
Conclusion
No animal model currently exists that enable the investigation of novel candidates for the treatment of peritumoral brain edema. With current interest in alternative treatments for peritumoral brain edema, there is an unmet need for clinically relevant animal models.
Funder
Brain Research UK
Candlelighters
Yorkshire's Brain Tumour Charity
Engineering and Physical Sciences Research Council
National Institute for Health and Care Research
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Neurology (clinical),Neurology,Oncology
Cited by
1 articles.
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