Updates on the WHO diagnosis of IDH-mutant glioma
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Published:2023-01-30
Issue:3
Volume:162
Page:461-469
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ISSN:0167-594X
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Container-title:Journal of Neuro-Oncology
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language:en
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Short-container-title:J Neurooncol
Abstract
Abstract
Purpose
The WHO classification of Tumors of the Central Nervous System represents the international standard classification for brain tumors. In 2021 the 5th edition (WHO CNS5) was published, and this review summarizes the changes regarding IDH-mutant gliomas and discusses unsolved issues and future perspectives.
Methods
This review is based on the 5th edition of the WHO Blue Book of CNS tumors (WHO CNS5) and relevant related papers.
Results
Major changes include taxonomy and nomenclature of IDH-mutant gliomas. Essential and desirable criteria for classification were established considering technical developments. For the first time molecular features are not only relevant for the classification of IDH-mutant gliomas but may impact grading as well.
Conclusion
WHO CNS5 classification moves forward towards a classification which is founded on tumor biology and serves clinical needs. The rapidly increasing knowledge on the molecular landscape of IDH-mutant gliomas is expected to further refine classification and grading in the future.
Funder
Universitätsklinikum Heidelberg
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Neurology (clinical),Neurology,Oncology
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