Amino-acid PET as a prognostic tool after post Stupp protocol temozolomide therapy in high-grade glioma patients
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Published:2024-06-06
Issue:2
Volume:169
Page:241-245
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ISSN:0167-594X
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Container-title:Journal of Neuro-Oncology
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language:en
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Short-container-title:J Neurooncol
Author:
Zinsz Adeline,Ahrari Shamimeh,Becker Jason,Mortada Ali,Roch Veronique,Doriat Louis,Santi Matthieu,Blonski Marie,Taillandier Luc,Zaragori Timothée,Verger Antoine
Abstract
Abstract
Purpose
This study aimed to evaluate the prognostic performance of amino-acid PET in high-grade gliomas (HGG) patients at the time of temozolomide (TMZ) treatment discontinuation, after the Stupp protocol.
Methods
The analysis included consecutive HGG patients with dynamic [18F]FDOPA PET imaging within 3 months of the end of TMZ therapy, post-Stupp protocol. Static and dynamic PET parameters, responses to RANO criteria for MRI and clinical and histo-molecular factors were correlated to progression-free (PFS).
Results
Thirty-two patients (59.4 [54.0;67.6] years old, 13 (41%) women) were included. Static PET parameters peak tumor-to-background ratio and metabolic tumor volume (respective thresholds of 1.9 and 1.5 mL) showed the best 84% accuracies for predicting PFS at 6 months (p = 0.02). These static PET parameters were also independent predictor of PFS in multivariate analysis (p ≤ 0.05).
Conclusion
In HGG patients having undergone a Stupp protocol, the absence of significant PET uptake after TMZ constitutes a favorable prognostic factor.
Publisher
Springer Science and Business Media LLC
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