Effect of Surgically Induced Weight Loss on Pelvic Organ Prolapse: A Meta-analysis

Author:

Tian Zhao,Wang Xiuqi,Hu Xiaopeng,Sun ZhijingORCID

Abstract

Abstract Introduction Bariatric surgery alleviates certain aspects of pelvic floor disorder, but the effect on pelvic organ prolapse (POP) is unclear. To assess the effect of bariatric surgery on POP we conducted the present meta-analysis and firstly performed a subgroup analysis based on the duration of follow-up. Methods Four databases including PubMed, The Cochrane Library, Web of Science, and Embase were searched to identify relevant studies published before February 24, 2023. The main outcome was the prevalence and severity of POP symptoms before and after bariatric surgery. Then we assessed the heterogeneity, publication bias and performed subgroup analyses based on follow-up time, study quality and region. Results Eleven studies with a total of 696 participants met the inclusion criteria. The results showed that the prevalence of POP decreased after bariatric surgery (odds ratio[OR] = 2.29, 95% confidence interval[CI]: 1.05, 5.01; P = 0.04, I2 = 78%), with significant differences observed both at 3–6 months (OR = 2.24, 95% CI: 1.25, 4.01; P = 0.007, I2 = 59%) and 12 months (OR = 4.64, 95% CI: 2.83, 7.58; P < 0.0001, I2 = 0%) of follow-up compared with pre-surgery. Pelvic Organ Prolapse Distress Inventory scores 6-item also decreased after bariatric surgery (mean difference [MD] = 2.11, 95% CI: 0.32, 3.89; P = 0.02, I2 = 55%) with significant differences observed both at 3–6 months (MD = 3.72; 95% CI: [0.10, 7.34], P = 0.04, I2 = 70%) and ≥ 12 months (MD = 3.24; 95% CI: [0.56, 5.91], P = 0.02, I2 = 56%) of follow-up. Conclusion Bariatric surgery alleviated POP symptoms in women with obesity both during short-term (3–6 months) and long-term (≥ 12 months) follow-up. Graphical Abstract

Funder

Natural Science Foundation of Beijing Municipality

National Natural Science Foundation of China

Chinese Academy of Medical Sciences Initiative for Innovative Medicine

Publisher

Springer Science and Business Media LLC

Subject

Nutrition and Dietetics,Endocrinology, Diabetes and Metabolism,Surgery

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