Coexisiting type 1 diabetes and celiac disease is associated with lower Hba1c when compared to type 1 diabetes alone: data from the Australasian Diabetes Data Network (ADDN) registry
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Published:2023-06-20
Issue:11
Volume:60
Page:1471-1477
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ISSN:1432-5233
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Container-title:Acta Diabetologica
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language:en
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Short-container-title:Acta Diabetol
Author:
James StevenORCID, Perry Lin, Lowe Julia, Donaghue Kim C., Pham-Short Anna, Craig Maria E.ORCID, Ambler Geoff, Anderson Kym, Andrikopoulos Sof, Batch Jenny, Brown Justin, Cameron Fergus, Colman Peter G., Conwell Louise, Cotterill Andrew, Couper Jennifer, Davis Elizabeth, de Bock Martin, Fairchild Jan, Fegan Gerry, Fourlanos Spiros, Glastras Sarah, Goss Peter, Gray Leonie, Hamblin Peter Shane, Hofman Paul, Holmes-Walker Dianne Jane, Huynh Tony, Isaacs Sonia, Jefferies Craig, Johnson Stephanie, Jones Tim, Kao Jeff, King Bruce R., Lafferty Antony, Martin Michelle, McCrossin Robert, Neville Kris, Pascoe Mark, Paul Ryan, Peña Alexia, Phillips Liza, Price Darrell, Rodda Christine, Simmons David, Sinnott Richard, Smart Carmel, Stone Monique, Stranks Steve, Tham Elaine, Waddell Barbara, Ward Glenn, Wheeler Ben, Woodhead Helen, Zimmermann Anthony,
Abstract
Abstract
Aim
To compare HbA1c and clinical outcomes in adolescents and young adults with type 1 diabetes (T1D), with or without celiac disease (CD).
Methods
Longitudinal data were extracted from ADDN, a prospective clinical diabetes registry. Inclusion criteria were T1D (with or without CD), ≥ 1 HbA1c measurement, age 16–25 years and diabetes duration ≥ 1 year at last measurement. Multivariable Generalised Estimated Equation models were used for longitudinal analysis of variables associated with HbA1c.
Results
Across all measurements, those with coexisting T1D and CD had lower HbA1c when compared to those with T1D alone (8.5 ± 1.5% (69.4 ± 16.8 mmol/mol) vs. 8.7 ± 1.8% (71.4 ± 19.8 mmol/mol); p < 0.001); lower HbA1c was associated with shorter diabetes duration (B = − 0.06; 95% CI − 0.07 to − 0.05; p < 0.001), male sex (B = − 0.24; − 0.36 to − 0.11; p < 0.001), insulin pump therapy use (B = − 0.46; − 0.58 to − 0.34; p < 0.001), coexistence of T1D and CD (B = − 0.28; − 0.48 to − 0.07; p = 0.01), blood pressure (B = − 0.16; − 0.23 to − 0.09; p < 0.001) and body mass index (B = -− 0.03; − 0.02 to − 0.04; p = 0.01) in the normal range. At last measurement, 11.7% of the total population had a HbA1c < 7.0% (53.0 mmol/mol).
Conclusions
Across all measurements, coexisting T1D and CD is associated with lower HbA1c when compared to T1D alone. However, HbA1c is above target in both groups.
Funder
University of the Sunshine Coast
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine
Reference30 articles.
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