Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs
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Published:2020-07-18
Issue:1
Volume:36
Page:105-114
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ISSN:0910-8327
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Container-title:Heart and Vessels
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language:en
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Short-container-title:Heart Vessels
Author:
Tabata Tokiko, Yamashita TomoyaORCID, Hosomi Koji, Park Jonguk, Hayashi Tomohiro, Yoshida Naofumi, Saito Yoshihiro, Fukuzawa Koji, Konishi Kana, Murakami Haruka, Kawashima Hitoshi, Mizuguchi Kenji, Miyachi Motohiko, Kunisawa Jun, Hirata Ken-ichi
Abstract
AbstractAtrial fibrillation (AF) reduces the quality of life by triggering stroke and heart failure. The association between AF onset and gut metabolites suggests a causal relationship between AF and gut microbiota dysbiosis; however, the relationship remains poorly understood. We prospectively enrolled 34 hospitalized patients with AF and 66 age-, sex-, and comorbidity-matched control subjects without a history of AF. Gut microbial compositions were evaluated by amplicon sequencing targeting the 16S ribosomal RNA gene. We assessed differences in dietary habits by using a brief-type self-administered diet history questionnaire (BDHQ). Gut microbial richness was lower in AF patients, although the diversity of gut microbiota did not differ between the two groups. At the genus level, Enterobacter was depleted, while Parabacteroides, Lachnoclostridium, Streptococcus, and Alistipes were enriched in AF patients compared to control subjects. The BDHQ revealed that the intake of n-3 polyunsaturated fatty acids and eicosadienoic acid was higher in AF patients. Our results suggested that AF patients had altered gut microbial composition in connection with dietary habits.
Funder
Japan Society for the Promotion of Science KAKENHI PRIME from the Japan Agency Medical Research and Development the Japan Agency for Medical Research and Development
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine
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