Abstract
Abstract
The use of glass for pharmaceutical new applications such as high-technology drugs, requires the strictest container inertness. A common theme of paramount importance in glass container integrity preservation is the detailed mechanism driving the sudden failure due the crack propagation. Using a combination of discrete element method (DEM) and finite element method (FEM), a stress map for glass cartridges packed into an accumulation table and transported by a conveyor belt at a fixed velocity is obtained under realistic conditions. The DEM calculation provides a full description of the dynamics of the cartridges, as approximated by an equivalent sphere, as well as the statistics of the multiple collisions. The FEM calculation exploits this input to provide the maximum principal stress of different pairs as a function of time. Our analysis shows that, during their transportation on the conveyor belt, the cartridges are subject to several shocks of varying intensities. Under these conditions, a crack may originate inside the cartridge in the area of maximal tensile stress, and propagate outward. Estimated stresses are found in good agreement with real systems.
Graphic abstract
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,Mechanics of Materials,General Materials Science
Reference24 articles.
1. Schaut, R.A., Weeks, P.W.: Historical review of glasses used for parenteral packaging. PDA J. Pharm. Sci. Technol. 71, 279 (2017)
2. Mould, R.E.: In: Bonis, L.J., Duga, J.J., Gilman, J.J. (eds.) Fracture of Metals, Polymers, and Glasses. Springer, Berlin (1967)
3. Yoritomo J.Y., Weaver R.L.: Slow dynamics in a single glass bead. arXiv:1909.07799v1 [cond-mat]
4. Janda, A., Zuriguel, I., Garcimartin, A., Maza, D.: Clogging of granular materials in narrow vertical pipes discharged at constant velocity. Granul. Matter 17, 545–551 (2015)
5. Perng, A.T.H., Capart, H., Chou, H.T.: Granular configurations, motions, and correlations in slow uniform flows driven by an incline conveyor belt. Granul. Matter 8, 5–17 (2006)
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献