Effect of topical application of clotrimazole to rats on epidermal and hepatic monooxygenase activities and cytochrome P-450

Author:

Merk H. F.,Khan W. A.,Kuhn C.,Bickers D. R.,Mukhtar H.

Publisher

Springer Science and Business Media LLC

Subject

Dermatology,General Medicine

Reference27 articles.

1. Bickers DR, Dutta-Choudhury T, Mukhtar H (1982) Epidermis: a site of drug metabolism in neonatal rat skin. Studies on cytochrome P-450 content and mixed-function oxidase and epoxide hydrolase activity. Mol Pharmacol 21:239?247

2. Black SD, Coon MJ (1986) Comparative structures of P-450 cytochromes. In: Ortiz de Montellano PR (ed) Cytochrome P-450: structure, metabolism and biochemistry. Plenum Press, New York, pp 161?216

3. Epstein EH Jr, Munderloh NL, Fukuyama K (1979) Dithiothreitol separation of newborn rodent dermis and epidermis. J Invest Dermatol 73:207?210

4. Greenlee, WF, Poland A (1978) An improved assay of 7-ethoxycoumarin-O-deethylase activity: induction of hepatic enzyme activity in C57BI/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Pharmacol Exp Ther 205:596?605

5. Khan WA, Kuhn C, Merk HF, Park SS, Gelboin HV, Bickers DR, Mukhtar H (1989) Isozyme specific monoclonal antibody directed assessment of induction of hepatic cytochrome P-450 by clotrimazole. Drug Metab Dispos 17 (in press)

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