Distribution of the novel anticancer drug candidate brequinar sodium (DuP 785, NSC 368390) into normal and tumor tissues of nude mice bearing human colon carcinoma xenografts

Author:

Shen Huey-shin L.,Chen Shih-Fong,Behrens Davette L.,Whitney Charles C.,Dexter Daniel L.,Forbes Martin

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference8 articles.

1. Chen SF, Ruben RL, Dexter DL (1986) Mechanism of action of the novel anticancer agent 6-fluoro-2-(2?-fluoro-1,1?-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis. Cancer Res 46: 5014?5019

2. Dexter DL, Barbosa JA, Calabresi P (1979) N,N-Dimethyl-formamide-induced alteration of cell culture characteristics and loss of tumorigenicity in cultured human colon carcinoma cells. Cancer Res 39: 1020?1025

3. Dexter DL, Spremulli EN Fligiel A, Barbosa JA, Vogel R, Van Voorhees A, Calabresi P (1981) Heterogeneity of cancer cells from a single human colon carcinoma. Am J Med 71: 949?956

4. Dexter DL, Hesson DP, Ardecky RJ, Ganti VR, Tippett DL, Dusak BA, Paull KD, Plowman J, DeLarco BM, Narayanan VL, Forbes M (1985) Activity of a novel 4-quinolinecarboxylic acid, NSC 368390 [6-Fluoro-2-(2?-fluoro-1,1?-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium salt, against experimental tumors. Cancer Res 45: 5563?5568

5. Fodstad O, Hansen CT, Cannon GB, Statham CN, Lichtenstein GR, Boyd MR (1984) Lack of correlation between natural killer activity and tumor control in nude mice with different immune defects. Cancer Res 44: 4403?4408

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5. B;Hagers Handbuch der Pharmazeutischen Praxis;1999

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