A comparison of iodine and indium labelled anti CEA intact antibody, F(ab)2 and Fab fragments by imaging tumour xenografts

Author:

Andrew Sarah M.,Perkins Alan C.,Pimm Malcolm V.,Baldwin Robert W.

Publisher

Springer Science and Business Media LLC

Subject

Radiology, Nuclear Medicine and imaging,General Medicine,Radiology, Nuclear Medicine and imaging,General Medicine

Reference18 articles.

1. Andrew SM, Pimm MV, Perkins AC, Baldwin RW (1986) Comparative imaging and biodistribution studies with an anti-CEA monoclonal antibody and its F(ab)2 and Fab fragments in mice with colon carcinoma xenografts. Eur J Nucl Med 12:168–175

2. Arend WP, Silverblatt FJ (1975) Serum disappearance and catabolism of homologous immunoglobulin fragments in rats. Clin Exp Immunol 22:502–513

3. Buchegger F, Haskell CM, Scheryer M, Scazziga BR, Randin S, Carrel S, Mach JP (1983) Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude mice. J Exp Med 158:413–427

4. Buraggi GL, Gallegaro L, Turrin A, Cascinelli N, Attili A, Emanuelli H, Gasparini M, Deleide G, Plassio G, Dovis M, Mariani G, Natali PG, Scassellati GA, Rosa U, Ferrone S (1984) Immunoscintigraphy with123I,99mTc and111 In-labelled F(ab′)2 fragments of monoclonal antibodies to a human high molecular weight-melanoma associated antigen. J Nucl Med Allied Sci 28:283–295

5. Childs RL, Hnatowich DJ (1985) Optimum conditions for labelling of DTPA-coupled antibodies with technetium-99m. J Nucl Med 26:292–299

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