Rheumatoid arthritis study of the Egyptian College of Rheumatology (ECR): nationwide presentation and worldwide stance
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Published:2023-01-08
Issue:4
Volume:43
Page:667-676
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ISSN:1437-160X
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Container-title:Rheumatology International
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language:en
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Short-container-title:Rheumatol Int
Author:
Gheita Tamer A.ORCID, Raafat Hala A.ORCID, El-Bakry Samah A.ORCID, Elsaman AhmedORCID, El-Saadany Hanan M.ORCID, Hammam NevinORCID, El-Gazzar Iman I.ORCID, Samy NermeenORCID, Elsaid Nora Y.ORCID, Al-Adle Suzan S.ORCID, Tharwat SamarORCID, Ibrahim Amira M.ORCID, Fawzy Samar M.ORCID, Eesa Nahla N.ORCID, Shereef Rawhya ElORCID, Ismail FatenORCID, Elazeem Mervat I AbdORCID, Abdelaleem Enas A.ORCID, El-Bahnasawy AmanyORCID, Selim Zahraa I.ORCID, Gamal Nada M.ORCID, Nassr MahaORCID, Nasef Samah I.ORCID, Moshrif Abdel HafeezORCID, Elwan ShereenORCID, Abdel-Fattah Yousra H.ORCID, Amer Marwa A.ORCID, Mosad DoaaORCID, Mohamed Eman F.ORCID, El-Essawi Dina F.ORCID, Taha HananORCID, Salem Mohamed N.ORCID, Fawzy Rasha M.ORCID, Ibrahim Maha E.ORCID, Khalifa AsmaaORCID, Abaza Nouran M.ORCID, Abdalla Ahmed M.ORCID, El-Najjar Amany R.ORCID, Azab Noha A.ORCID, Fathi Hanan M.ORCID, El-Hadidi KhaledORCID, El-Hadidi TahsinORCID,
Abstract
AbstractTo depict the spectrum of rheumatoid arthritis (RA) in Egypt in relation to other universal studies to provide broad-based characteristics to this particular population. This work included 10,364 adult RA patients from 26 specialized Egyptian rheumatology centers representing 22 major cities all over the country. The demographic and clinical features as well as therapeutic data were assessed. The mean age of the patients was 44.8 ± 11.7 years, disease duration 6.4 ± 6 years, and age at onset 38.4 ± 11.6 years; 209 (2%) were juvenile-onset. They were 8750 females and 1614 males (F:M 5.4:1). 8% were diabetic and 11.5% hypertensive. Their disease activity score (DAS28) was 4.4 ± 1.4 and health assessment questionnaire (HAQ) 0.95 ± 0.64. The rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) were positive in 73.7% and 66.7% respectively. Methotrexate was the most used treatment (78%) followed by hydroxychloroquine (73.7%) and steroids (71.3%). Biologic therapy was received by 11.6% with a significantly higher frequency by males vs females (15.7% vs 10.9%, p = 0.001). The least age at onset, F:M, RF and anti-CCP positivity were present in Upper Egypt (p < 0.0001), while the highest DAS28 was reported in Canal cities and Sinai (p < 0.0001). The HAQ was significantly increased in Upper Egypt with the least disability in Canal cities and Sinai (p = 0.001). Biologic therapy intake was higher in Lower Egypt followed by the Capital (p < 0.0001). The spectrum of RA phenotype in Egypt is variable across the country with an increasing shift in the F:M ratio. The age at onset was lower than in other countries.
Publisher
Springer Science and Business Media LLC
Subject
Immunology,Immunology and Allergy,Rheumatology
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