Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: effect on the expression of chemokine and adhesion molecule
Author:
Publisher
Springer Science and Business Media LLC
Subject
Immunology,Immunology and Allergy,Rheumatology
Link
http://link.springer.com/content/pdf/10.1007/s00296-009-0953-0.pdf
Reference19 articles.
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2. Nishimoto N, Yoshizaki K, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T et al (2004) Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum 50:1761–1769. doi: 10.1002/art.20303
3. Smolen JS, Beaulieu A, Rubbert-Roth A, Ramos-Remus C, Rovensky J, Alecock E et al (2008) Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet 371:987–997. doi: 10.1016/S0140-6736(08)60453-5
4. Uchiyama Y, Yorozu K, Hashizume M, Moriya Y, Mihara M (2008) Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis. Biol Pharm Bull 31:1159–1163. doi: 10.1248/bpb.31.1159
5. Pals ST, Horst E, Scheper RJ, Meijer CJ (1989) Mechanisms of human lymphocyte migration and their role in the pathogenesis of disease. Immunol Rev 108:111–133. doi: 10.1111/j.1600-065X.1989.tb00015.x
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