Exploratory analyses assessing the impact of early tumour shrinkage and depth of response on survival outcomes in patients with RAS wild-type metastatic colorectal cancer receiving treatment in three randomised panitumumab trials

Author:

Taieb JulienORCID,Rivera Fernando,Siena Salvatore,Karthaus Meinolf,Valladares-Ayerbes Manuel,Gallego Javier,Geissler Michael,Koukakis Reija,Demonty Gaston,Peeters Marc

Funder

Amgen

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,General Medicine

Reference29 articles.

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2. Abad A, Massuti B, Grávalos C, Escudero P, Guillén-Ponce C, Manzano JL, Ortiz MJ, Safont MJ, Gallego J, Sastre J, Pericay C, Dueñas R, Rivera F, Losa F, Valladares-Ayerbes M, González E, Robles L, Aranda E, Carrato A, On behalf of the Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD) ( (2015) Early tumour shrinkage (ETS) and depth of response (DpR) with first-line panitumumab (P) plus FOLFOX4 (P-FOLFOX4) or FOLFIRI (P-FOLFIRI) in patients (pts) with wild-type (WT) RAS colorectal cancer (CRC) and liver-limited disease. Eur J Cancer 51(Suppl):S374–S375

3. Clarke CN, Kopetz ES (2015) BRAF mutant colorectal cancer as a distinct subset of colorectal cancer: clinical characteristics, clinical behavior, and response to targeted therapies. J Gastrointest Oncol 6:660–667

4. Contal C, O’Quigley J (1999) An application of changepoint methods in studying the effect of age on survival in breast cancer. Comput Stat Data Anal 30:253–270

5. Cremolini C, Loupakis F, Antoniotti C, Lonardi S, Masi G, Salvatore L, Cortesi E, Tomasello G, Spadi R, Zaniboni A, Tonini G, Barone C, Vitello S, Longarini R, Bonetti A, D’Amico M, Di Donato S, Granetto C, Boni L, Falcone A (2015) Early tumor shrinkage and depth of response predict long-term outcome in metastatic colorectal cancer patients treated with first-line chemotherapy plus bevacizumab: results from phase III TRIBE trial by the Gruppo Oncologico del Nord Ovest. Ann Oncol 26:1188–1194

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