A phase 1 study of IDH305 in patients with IDH1R132-mutant acute myeloid leukemia or myelodysplastic syndrome

Author:

DiNardo Courtney D.ORCID,Hochhaus Andreas,Frattini Mark G.,Yee Karen,Zander Thomas,Krämer Alwin,Chen Xueying,Ji Yan,Parikh Nehal S.,Choi Joanne,Wei Andrew H.

Funder

Novartis

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,General Medicine

Reference32 articles.

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2. de Botton S, Pollyea DA, Stein EM, DiNardo C, Fathi AT, Roboz GJ et al. (2015) Clinical safety and activity of AG-120, a first-in-class potent inhibitor of the IDH1 mutant protein, in a phase I study of patients with advanced IDH1-mutant hematologic malignancies. Poster presented at the 20th Annual Congress of the European Hematology Association, 11–14 June 2015, Vienna, Austria 100704: P563.

3. Cairns RA, Mak TW (2013) Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities. Cancer Discov 3(7):730–741

4. Cheson BD, Bennett JM, Kopecky KJ, Büchner T, Willman CL, Estey EH, Schiffer CA, Doehner H, Tallman MS, Lister TA, Lo-Coco F, Willemze R, Biondi A, Hiddemann W, Larson RA, Löwenberg B, Sanz MA, Head DR, Ohno R, Bloomfield CD, International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia (2003) Revised recommendations of the international working group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia. J Clin Oncol 21(24):4642–4649

5. Cheson BD, Greenberg PL, Bennett JM, Lowenberg B, Wijermans PW, Nimer SD, Pinto A, Beran M, de Witte TM, Stone RM, Mittelman M, Sanz GF, Gore SD, Schiffer CA, Kantarjian H (2006) Clinical application and proposal for modification of the international working group (IWG) response criteria in myelodysplasia. Blood 108(2):419–425

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