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Interferon-γ predicts the treatment efficiency of immune checkpoint inhibitors in cancer patients

  • Published:2022-07-19 Issue: Volume: Page:
  • ISSN:0171-5216
  • Container-title:Journal of Cancer Research and Clinical Oncology
  • language:en
  • Short-container-title:J Cancer Res Clin Oncol

Author:

Liu Jing,Ma Jingtao,Xing Na,Ji Zhengzheng,Li Jiasong,Zhang Shasha,Guo Zhanjun

Funder

the Foundation of Hebei Provincial Department of Science and Technology & Hebei Medical University

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,General Medicine

Reference39 articles.

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2. Brahmer J, Lacchetti C, Schneider B, Atkins M, Brassil K, Caterino J, Chau I, Ernstoff M, Gardner J, Ginex P, Hallmeyer S, Holter CJ, Leighl N, Mammen J, McDermott D, Naing A, Nastoupil L, Phillips T, Porter L, Puzanov I, Reichner C, Santomasso B, Seigel C, Spira A, Suarez-Almazor M, Wang Y, Weber J, Wolchok J, Thompson J (2018) Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American society of clinical oncology clinical practice guideline. J Clin Oncol 36:1714–1768. https://doi.org/10.1200/jco.2017.77.6385

3. Briesemeister D, Sommermeyer D, Loddenkemper C, Loew R, Uckert W, Blankenstein T, Kammertoens T (2011) Tumor rejection by local interferon gamma induction in established tumors is associated with blood vessel destruction and necrosis. Int J Cancer 128(371):378. https://doi.org/10.1002/ijc.25350

4. Bromberg J, Horvath C, Wen Z, Schreiber R, Darnell JE (1996) Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proc Nat Acad Sci USA 93:7673–7678. https://doi.org/10.1073/pnas.93.15.7673

5. Chin Y, Kitagawa M, Su W, You Z, Iwamoto Y, Fu XJS (1996) Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science 272:719–722. https://doi.org/10.1126/science.272.5262.719

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