Author:
Zhu Mingjing,Li Pian,Zhang Huisi,Wu Lanhua,Min Kang
Abstract
Abstract
Objective
The International Union for Cancer Control/American Joint Committee on Cancer (UICC/AJCC) rT staging is not clinically practical for recurrent nasopharyngeal carcinoma (rNPC). The aim of this study was to establish a new rT staging to guide the treatment of rNPC.
Methods
We conducted a retrospective analysis of 175 patients diagnosed with rNPC between January 2012 and December 2020, using ROC curve analysis to evaluate its effectiveness.
Results
We analyzed the overall survival (OS) and progression-free survival(PFS) of patients diagnosed with rNPC according to the 8th (UICC/AJCC) rT staging, and found that the overall survival of rT1 and rT2 patients (OS; 29.98% vs. 27.09%, p = 0.8059) and progression-free survival (PFS; 28.48% vs. 26.12%, p = 0.4045) had no significant difference. In rT1 and rT2 patients of this study, overall survival(OS; 30.44% vs. 24.91%, p = 0.0229) and progression-free survival(PFS 29.12% vs. 24.03%, p = 0.0459) had a significant difference. Smoking, family history, and time interval of initial recurrence were independent prognostic factors for OS and PFS.
Conclusion
The new rT staging of this study has a better predictive value for survival of rNPC patients than the 8th (UICC/AJCC) rT staging.
Funder
the National Natural Science Foundation of China
The Research Foundation of the Science and Technology Department of Guangxi Province, China
the Research Foundation of the Health Department of Guangxi Province, China
Guangxi Medical High-level Talents Training Program. The central government guide local science and technology development projects
Guangxi Medical University Training Program for Distinguished Young Scholars
Medical Excellence Award Funded by the Creative Research Development Grant from the First Affiliated Hospital of Guangxi Medical University
Publisher
Springer Science and Business Media LLC
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