Abstract
AbstractSignificant reprogramming of epigenome is widely described during pathogenesis of breast cancer. Transformation of normal cell to hyperplastic cell and to neoplastic phenotype is associated with aberrant DNA (de)methylation, which, through promoter and enhancer methylation changes, activates oncogenes and silence tumor suppressor genes in variety of tumors including breast. DNA methylation, one of the major epigenetic mechanisms is catalyzed by evolutionarily conserved isoforms namely, DNMT1, DNMT3A and DNMT3B in humans. Over the years, studies have demonstrated intricate and complex regulation of DNMT isoforms at transcriptional, translational and post-translational levels. The recent findings of allosteric regulation of DNMT isoforms and regulation by other interacting chromatin modifying proteins emphasizes functional integrity and their contribution for the development of breast cancer and progression. DNMT isoforms are regulated by several intrinsic and extrinsic parameters. In the present review, we have extensively performed bioinformatics analysis of expression of DNMT isoforms along with their transcriptional and post-transcriptional regulators such as transcription factors, interacting proteins, hormones, cytokines and dietary elements along with their significance during pathogenesis of breast tumors. Our review manuscript provides a comprehensive understanding of key factors regulating DNMT isoforms in breast tumor pathology and documents unsolved issues.
Funder
Department of Biotechnology , Ministry of Science and Technology
Council of Scientific and Industrial Research, India
Manipal Academy of Higher Education, Manipal
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,General Medicine
Reference332 articles.
1. Abdelmohsen K, Pullmann R, Lal A et al (2007) Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell 25:543–557. https://doi.org/10.1016/j.molcel.2007.01.011
2. Abdelmohsen K, Kuwano Y, Kim HH, Gorospe M (2008) Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence. Biol Chem 389:243–255. https://doi.org/10.1515/BC.2008.022
3. Abercrombie HC, Giese-Davis J, Sephton S et al (2004) Flattened cortisol rhythms in metastatic breast cancer patients. Psychoneuroendocrinology 29:1082–1092. https://doi.org/10.1016/j.psyneuen.2003.11.003
4. Adams J, Carder PJ, Downey S et al (2000) Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen. Cancer Res 60:2898–2905
5. Agoston AT, Argani P, Yegnasubramanian S et al (2005) Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer. J Biol Chem 280:18302–18310. https://doi.org/10.1074/jbc.M501675200
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献