Author:
Liu Rui,Ren Tingting,Li Jing,Wang Nan,Xu Liangyuan,Guo Qihan,Zhang Hong,Ma Jianmin
Abstract
Abstract
Purpose
The incidence of lacrimal gland adenocarcinoma is low. This study was designed to analyze the clinical and prognostic characteristics of lacrimal gland adenocarcinoma.
Methods
This was a clinical study and literature review; 25 patients diagnosed with lacrimal gland adenocarcinoma by histopathology were enrolled and their medical history data were collected.
Results
The incidence of bone destruction and surrounding tissue invasion was 52% and 44%, respectively. The incidence of distant metastasis of lacrimal gland adenocarcinoma was about 50%. The 5-year overall survival rate of death or metastasis was 33.5%. Age, sex, laterality, tumor size, pathology type, bone destruction, nerve or perineural invasion, invasion of peripheral tissue, T stage, AR, Her-2 and treatment had no significant correlation with lacrimal adenocarcinoma’s prognosis (P > 0.05), while the higher expression of Ki-67 may have higher risk of death or metastasis (P = 0.020).
Conclusion
The incidence of bone destruction and distant metastasis of lacrimal adenocarcinoma is high and the imaging examination is necessary to assess the risk of distant metastasis. The 5-year survival rate of death or metastasis is 33.5% and the high expression of Ki-67 predicts poor prognosis of lacrimal adenocarcinoma.
Funder
Beijing Hospitals Authority’ Ascent Plan
Natural Science Foundation of Beijing
Beijing Science and Technology Rising Star Program - Cross-cooperation
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,General Medicine
Reference36 articles.
1. Alkatan H, Roberts F, White VA (2018) Adenocarcinoma of the lacrimal gland. In: Grossniklaus HE, Eberhart CG, Kivelä TT (eds) WHO classification of tumours of the eye. WHO Press, Geneva
2. Andreasen S, Grauslund M, Heegaard S (2017) Lacrimal gland ductal carcinomas: clinical, morphological and genetic characterization and implications for targeted treatment. Acta Ophthalmol 95(3):299–306. https://doi.org/10.1111/aos.13310
3. Andreoli MT, Aakalu V, Setabutr P (2015) Epidemiological trends in malignant lacrimal gland tumors. Otolaryngol Head Neck Surg 152(2):279–283. https://doi.org/10.1177/0194599814556624
4. Anestis A, Zoi I, Papavassiliou AG, Karamouzis MV (2020) Androgen receptor in breast cancer-clinical and preclinical research insights. Molecules 25(2):358. https://doi.org/10.3390/molecules25020358
5. Ashok Kumar P, Paulraj S, Mirchia K et al (2020) Ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland: a rare and morbid malignancy. Case Rep Oncol Med 2020:1790106. https://doi.org/10.1155/2020/1790106