Detection of MET amplification by droplet digital PCR in peripheral blood samples of non-small cell lung cancer

Author:

Fan Ying,Sun Rui,Wang Zhizhong,Zhang Yuying,Xiao Xiao,Liu Yizhe,Xin Beibei,Xiong Hui,Lu Daru,Ma JieORCID

Funder

Major public welfare projects in Henan Province Research and development of new technologies for tumor liquid biopsy and immunotherapy.

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,General Medicine

Reference59 articles.

1. Ahn BC, Lee JH, Kim MH, Pyo KH, Lee CK, Lim SM, Kim HR, Cho BC, Hong MH (2021) Distinct characteristics and clinical outcomes to predict the emergence of MET amplification in patients with non-small cell lung cancer who developed resistance after treatment with epidermal growth factor receptor tyrosine kinase inhibitors. Cancers (basel). https://doi.org/10.3390/cancers13123096

2. Angevin E, Spitaleri G, Rodon J, Dotti K, Isambert N, Salvagni S, Moreno V, Assadourian S, Gomez C, Harnois M et al (2017) A first-in-human phase I study of SAR125844, a selective MET tyrosine kinase inhibitor, in patients with advanced solid tumours with MET amplification. Eur J Cancer 87:131–139. https://doi.org/10.1016/j.ejca.2017.10.016

3. Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, Chitale D, Motoi N, Szoke J, Broderick S et al (2007) MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA 104:20932–20937. https://doi.org/10.1073/pnas.0710370104

4. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424. https://doi.org/10.3322/caac.21492

5. Camidge DR, Davies KD (2019a) MET copy number as a secondary driver of epidermal growth factor receptor tyrosine kinase inhibitor resistance in EGFR-mutant non-small-cell lung cancer. J Clin Oncol 37:855–857. https://doi.org/10.1200/JCO.19.00033

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