The GALAD score and the BALAD-2 score correlate with transarterial and systemic treatment response and survival in patients with hepatocellular carcinoma
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Published:2024-02-06
Issue:2
Volume:150
Page:
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ISSN:1432-1335
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Container-title:Journal of Cancer Research and Clinical Oncology
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language:en
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Short-container-title:J Cancer Res Clin Oncol
Author:
Olbrich Anne, Niemeyer Johannes, Seiffert Hendrik, Ebel Sebastian, Gros Olga, Lordick Florian, Forstmeyer Dirk, Seehofer Daniel, Rademacher Sebastian, Denecke Timm, Matz-Soja Madlen, Berg Thomas, van Bömmel FlorianORCID
Abstract
Abstract
Purpose
The GALAD score and the BALAD-2 score are biomarker-based scoring systems used to detect hepatocellular carcinoma (HCC). Both incorporate levels of alpha-fetoprotein (AFP), lens culinaris agglutinin-reactive AFP (AFP-L3), and des-gamma-carboxy prothrombin (DCP). Our objective was to examine the relationship between the GALAD score as well as the BALAD-2 score and treatment response to transarterial or systemic treatments in patients with HCC.
Methods
A total of 220 patients with HCC treated with either transarterial (n = 121) or systemic treatments (n = 99; mainly Sorafenib) were retrospectively analyzed. The GALAD score and the BALAD-2 score were calculated based on AFP-L3, AFP, and DCP levels measured in serum samples collected before treatment. The results were correlated with 3-month treatment efficacy based on radiologic mRECIST criteria.
Results
The GALAD score showed a strong correlation with BCLC stage (p < 0.001) and total tumor diameter before treatment (p < 0.001).The GALAD score at baseline was significantly lower in patients with a 3-month response to transarterial (p > 0.001) than in refractory patients. Among patients receiving systemic treatment, the median BALAD-2 score at baseline showed a strong association with response at month 3 (p < 0.001).
In the transarterial treatment group, the GALAD score (AUC = 0.715; p < 0.001) as well as the BALAD score (AUC = 0.696; p < 0.001) were associated with overall survival, hereby outperforming AFP, AFP-L3 and DCP.
Conclusion
The GALAD score as well as the BALAD-2 score hold significant promise as a prognostic tool for patients with early or intermediate-stage HCC who are undergoing transarterial or systemic treatments.
Funder
Universität Leipzig
Publisher
Springer Science and Business Media LLC
Reference31 articles.
1. Ahmed F, Onwumeh-Okwundu J, Yukselen Z, Endaya Coronel M-K, Zaidi M, Guntipalli P, Garimella V, Gudapati S, Mezidor MD, Andrews K, Mouchli M, Shahini E (2021) Atezolizumab plus bevacizumab versus sorafenib or atezolizumab alone for unresectable hepatocellular carcinoma: a systematic review. World J Gastron Oncol 13(11):1813–1832. https://doi.org/10.4251/wjgo.v13.i11.1813 2. Benson AB, D’Angelica MI, Abbott DE, Anaya DA, Anders R, Are C, Bachini M, Borad M, Brown D, Burgoyne A, Chahal P, Chang DT, Cloyd J, Covey AM, Glazer ES, Goyal L, Hawkins WG, Iyer R, Jacob R, Kelley RK, Kim R, Levine M, Palta M, Park JO, Raman S, Reddy S, Sahai V, Schefter T, Singh G, Stein S, Vauthey J-N, Venook AP, Yopp A, McMillian NR, Hochstetler C, Darlow SD (2021) Hepatobiliary cancers, version 2.2021, NCCN clinical practice guidelines in oncology. J Natl Comprehensive Cancer Network JNCCN 19(5):541–565. https://doi.org/10.6004/jnccn.2021.0022 3. Berhane S, Toyoda H, Tada T, Kumada T, Kagebayashi C, Satomura S, Schweitzer N, Vogel A, Manns MP, Benckert J, Berg T, Ebker M, Best J, Dechêne A, Gerken G, Schlaak JF, Weinmann A, Wörns MA, Galle P, Yeo W, Mo F, Chan SL, Reeves H, Cox T, Johnson P (2016) Role of the GALAD and BALAD-2 serologic models in diagnosis of hepatocellular carcinoma and prediction of survival in patients. Clin Gastroenterol Hepatol Off Clin Practice J Am Gastroenterol Assoc 14(6):875-886.e6. https://doi.org/10.1016/j.cgh.2015.12.042 4. Best J, Bechmann LP, Sowa J-P, Sydor S, Dechêne A, Pflanz K, Bedreli S, Schotten C, Geier A, Berg T, Fischer J, Vogel A, Bantel H, Weinmann A, Schattenberg JM, Huber Y, Wege H, von Felden J, Schulze K, Bettinger D, Thimme R, Sinner F, Schütte K, Weiss KH, Toyoda H, Yasuda S, Kumada T, Berhane S, Wichert M, Heider D, Gerken G, Johnson P, Canbay A (2020) GALAD score detects early hepatocellular carcinoma in an international cohort of patients with nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 18(3):728-735.e4. https://doi.org/10.1016/j.cgh.2019.11.012 5. Cerban R, Ester C, Iacob S, Grasu M, Pâslaru L, Dumitru R, Lupescu I, Constantin G, Croitoru A, Gheorghe L (2018) Predictive factors of tumor recurrence and survival in patients with hepatocellular carcinoma treated with transarterial chemoembolization. J Gastroin Liver Diseases JGLD 27(4):409–417. https://doi.org/10.15403/jgld.2014.1121.274.fcr
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