Abstract
Abstract
Purpose
To investigate the synergistic effect of vitamin D and neferine on the growth and metastasis of colorectal cancer (CRC).
Methods
The synergistic effect of biologically active form of vitamin D, VD3 and neferine on the treatment of CRC was investigated by bliss analysis. Colony formation and wound healing ability, migration and invasion ability, and epithelial mesenchymal transition of HCT-116 cells, as a response to the combination treatment with VD3 and neferine were evaluated.
Results
VD3 and neferine showed a synergistic effect on CRC cell growth at a relatively low dose. The wound healing and colony formation capacity, cell migration and invasion abilities were all decreased by combination use of VD3 and neferine, compared to the VD3 or neferine treated single group. Furthermore, VD3 and neferine significantly decreased the expressions of N-cadherin, vimentin, snail, and slug in HCT-116 cells.
Conclusion
These data suggest that neferine enhances the anticancer capability of VD3 and reduces the dose dependency of VD3. The combination of vitamin D with neferine appears to be a potential therapeutic strategy for CRC.
Funder
Natural Science Foundation of Guangxi Province
National Natural Science Foundation of China
2019 BaGui Scholars Program of Guangxi Zhuang Autonomous Region
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,General Medicine
Cited by
2 articles.
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1. Emerging perspectives: unraveling the anticancer potential of vitamin D3;Naunyn-Schmiedeberg's Archives of Pharmacology;2023-11-23
2. The impact of vitamin D on cancer: A mini review;The Journal of Steroid Biochemistry and Molecular Biology;2023-07