MAP3K4 kinase action and dual role in cancer

Author:

Huang Yuxin,Wang Guanwen,Zhang NingningORCID,Zeng XiaohuaORCID

Abstract

AbstractIt is commonly known that the MAPK pathway is involved in translating environmental inputs, regulating downstream reactions, and maintaining the intrinsic dynamic balance. Numerous essential elements and regulatory processes are included in this pathway, which are essential to its functionality. Among these, MAP3K4, a member of the serine/threonine kinases family, plays vital roles throughout the organism's life cycle, including the regulation of apoptosis and autophagy. Moreover, MAP3K4 can interact with key partners like GADD45, which affects organism's growth and development. Notably, MAP3K4 functions as both a tumor promotor and suppressor, being activated by a variety of factors and triggering diverse downstream pathways that differently influence cancer progression. The aim of this study is to provide a brief overview of physiological functions of MAP3K4 and shed light on its contradictory roles in tumorigenesis.

Funder

Chongqing Municipal Health and Health Commission

Chongqing Research Institute Performance Incentive Guide Special Project

Talent Program of Chongqing

Publisher

Springer Science and Business Media LLC

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