Author:
Hu Mengyuan,Li Xue,Jiang Zhenluo,Xia Qing,Hu Yaoren,Guo Junming,Fu Liyun
Abstract
AbstractHepatocellular carcinoma (HCC) is characterized by high morbidity and mortality, and a low 5-year survival rate. Exploring the potential molecular mechanisms, finding diagnostic biomarkers with high sensitivity and specificity, and determining new therapeutic targets for HCC are urgently needed. Circular RNAs (circRNAs) have been found to play a key role in the occurrence and development of HCC, while exosomes play an important role in intercellular communication; thus, the combination of circRNAs and exosomes may have inestimable potential in early diagnosis and curative therapy. Previous studies have shown that exosomes can transfer circRNAs from normal or abnormal cells to surrounding or distant cells; thereafter, circRNAs influence target cells. This review summarizes the recent progress regarding the roles of exosomal circRNAs in the diagnosis, prognosis, occurrence and development and immune checkpoint inhibitor and tyrosine kinase inhibitor resistance of HCC to provide inspiration for further research.
Funder
Zhejiang Medical Scientific Research Foundation
Key Laboratory of Diagnosis and Treatment of Digestive System tumors of Zhejiang Province
Applied Research Projects on Nonprofit Technology of Zhejiang Province
Project of NINGBO Leading_ Medical & Health Discipline
the K. C. Wong Magna Fund in Ningbo University
Natural Science Foundation of Zhejiang Province
Natural Science Foundation of Ningbo
Ningbo Clinical Research Center for Digestive System tumors
Ningbo HwaMei Key Research Fund
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Endocrine and Autonomic Systems,Endocrinology,Oncology,Endocrinology, Diabetes and Metabolism
Cited by
1 articles.
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