Author:
Li Junchuan,Zhu Yuzhou,Yang Lie,Wang Ziqiang
Abstract
AbstractThe symbiotic interaction between gut microbiota and the digestive tract is an important factor in maintaining the intestinal environment balance. Colorectal cancer (CRC) is a complex disease involving the interaction between tumour cells and a large number of microorganisms. The microbiota is involved in the occurrence, development and prognosis of colorectal cancer. Several microbiota species have been studied, such as Fusobacterium nucleatum (F.nucleatum), Enterotoxigenic Bacteroidesfragilis (ETBF), Streptococcus bovis (S. bovis), Lactobacillus, and Bifidobacterium. Studies about the interaction between microbiota and CRC were retrieved from Embase, PubMed, Ovid and Web of Science up to 21 Oct 2021. This review expounded on the effect of microbiota on CRC, especially the dysregulation of bacteria and carcinogenicity. The methods of gut microbiota modifications representing novel prognostic markers and innovative therapeutic strategies were also described.
Funder
Ministry of Science and Technology of the People’s Republic of China
Department of Science and Technology of Sichuan Province
1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University
1·3·5 project for disciplines of excellence-Clinical Research Incubation Project, and West China Hospital, Sichuan University
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Endocrine and Autonomic Systems,Endocrinology,Oncology,Endocrinology, Diabetes and Metabolism
Cited by
7 articles.
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