A 191-kb genomic fragment containing the human α-globin locus can rescue α-thalassemic mice
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics
Link
http://link.springer.com/content/pdf/10.1007/s00335-005-0089-9.pdf
Reference16 articles.
1. Al-Hasani K, Vadolas J, Voullaire L, Williamson R, Ioannou P (2004) Complementation of alpha-thalassemia in alpha-globin knockout mice with a 191 kb transgene containing the human alpha-globin locus. Transgenic Res 14: 235-243
2. Feng DX, Liu DP, Huang Y, Wu L, Li TC, et al. (2001) The expression of human alpha-like globin genes in transgenic mice mediated by bacterial artificial chromosome. Proc Natl Acad Sci U S A 98: 15073-15077
3. Gourdon G, Sharpe JA, Wells D, Wood WG, Higgs DR (1994) Analysis of a 70 kb segment of DNA containing the human zeta and alpha-globin genes linked to their regulatory element (HS-40) in transgenic mice. Nucleic Acids Res 22: 4139-4147
4. Hatton CS, Wilkie AO, Drysdale HC, Wood WG, Vickers MA, et al. (1990) Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster. Blood 76: 221-227
5. Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, et al. (1989) A review of the molecular genetics of the human alpha-globin gene cluster. Blood 73: 1081-1104
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