A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes
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Published:2020-02
Issue:1-2
Volume:31
Page:30-48
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ISSN:0938-8990
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Container-title:Mammalian Genome
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language:en
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Short-container-title:Mamm Genome
Author:
Kollmus HeikeORCID, , Fuchs Helmut, Lengger Christoph, Haselimashhadi Hamed, Bogue Molly A., Östereicher Manuela A., Horsch Marion, Adler Thure, Aguilar-Pimentel Juan Antonio, Amarie Oana Veronica, Becker Lore, Beckers Johannes, Calzada-Wack Julia, Garrett Lillian, Hans Wolfgang, Hölter Sabine M., Klein-Rodewald Tanja, Maier Holger, Mayer-Kuckuk Philipp, Miller Gregor, Moreth Kristin, Neff Frauke, Rathkolb Birgit, Rácz Ildikó, Rozman Jan, Spielmann Nadine, Treise Irina, Busch Dirk, Graw Jochen, Klopstock Thomas, Wolf Eckhard, Wurst Wolfgang, Yildirim Ali Önder, Mason Jeremy, Torres Arturo, Balling Rudi, Mehaan Terry, Gailus-Durner Valerie, Schughart KlausORCID, Hrabě de Angelis Martin
Abstract
AbstractThe collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed a comprehensive and comparative phenotyping screening to identify phenotypic differences and similarities between the eight founder strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone and cartilage, energy metabolism, eye and vision, immunology, lung function, neurology, nociception, and pathology were analyzed; in most traits from sixteen females and sixteen males. We identified over 270 parameters that were significantly different between strains. This study highlights the value of the founder and CC strains for phenotype-genotype associations of many genetic traits that are highly relevant to human diseases. All data described here are publicly available from the mouse phenome database for analyses and downloads.
Funder
Bundesministerium für Forschung und Technologie Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München Helmholtz-Gemeinschaft
Publisher
Springer Science and Business Media LLC
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