Export of proteins across membranes: The helix reversion hypothesis-Reference-Cited by-同舟云学术

Export of proteins across membranes: The helix reversion hypothesis

Published:1989-12-01 Issue:6 Volume:9 Page:737-745
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Shinde U. P.¹,Guru Row T. N.²,Mawal Y. R.³

Affiliation:

1. Division of Chemical Engineering, National Chemical Laboratory, Pune 411 008, India

2. Division of Physical Chemistry, Indian Institute of Science, Bangalore

3. Division of Biochemical Sciences, Division of Chemical Engineering, National Chemical Laboratory, Pune 411 008, India

Abstract

A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/9/6/737/472929/bsr0090737.pdf

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