Emapalumab: First Global Approval

Author:

Al-Salama Zaina T.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical)

Reference17 articles.

1. Daver N, McClain K, Allen CE, et al. A consensus review on malignancy-associated hemophagocytic lymphohistiocytosis in adults. Cancer. 2017;123(17):3229–40.

2. UK National Institute for Health Research. Emapalumab for primary haemophagocytic lymphohistiocytosis. 2018. http://www.io.nihr.ac.uk/ . Accessed 7 Dec 2018.

3. De Min C, Buatois V, Chatel L, et al. Interferon gamma (IFNg) is the driving mediator of secondary hemophagocytic lymphohistiocytosis (sHLH) in TLR9-mediated pathogenesis in mice and is correlated to disease parameters in children [abstract no. 3076]. Arthritis Rheumatol. 2015;67(Suppl. 10):3691–2.

4. Prencipe G, Caiello I, Pascarella A, et al. Neutralization of IFN-gamma reverts clinical and laboratory features in a mouse model of macrophage activation syndrome. J Allergy Clin Immunol. 2018;141(4):1439–49.

5. Jordan MB, Hildeman D, Kappler J, et al. An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood. 2004;104(3):735–43.

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