Mitigating Serious Adverse Events in Gene Therapy with AAV Vectors: Vector Dose and Immunosuppression
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical)
Link
https://link.springer.com/content/pdf/10.1007/s40265-023-01836-1.pdf
Reference109 articles.
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3. Friedman-Einat M, Grossman Z, Mileguir F, et al. Detection of adeno-associated virus type 2 sequences in the human genital tract. J Clin Microbiol. 1997;35:71–8. https://doi.org/10.1128/jcm.35.1.71-78.1997.
4. Manno CS, Pierce GF, Arruda VR, et al. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat Med. 2006;12:342–7. https://doi.org/10.1038/nm1358.
5. Mingozzi F, Maus MV, Hui DJ, et al. CD8+ T-cell responses to adeno-associated virus capsid in humans. Nat Med. 2007;13:419–22. https://doi.org/10.1038/nm1549.
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