Upadacitinib: First Approval

Author:

Duggan Sean,Keam Susan J.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical)

Reference37 articles.

1. Genovese MC, Fleischmann R, Combe B, et al. Safety and efficacy of upadacitinib in patients with active rheumatoid arthritis refractory to biologic disease-modifying anti-rheumatic drugs (SELECT-BEYOND): a double-blind, randomised controlled phase 3 trial. Lancet. 2018;391(10139):2513–24.

2. AbbVie. AbbVie receives FDA approval of RINVOQTM (upadacitinib), an oral JAK inhibitor for the treatment of moderate to severe rheumatoid arthritis [media release]. 16 Aug 2019. http://www.abbvie.com .

3. AbbVie. RINVOQ™ (upadacitinib) extended-release tablets, for oral use: US prescribing information. 2019. https://www.accessdata.fda.gov/scripts/cder/daf/ . Accessed 2019.

4. Parmentier JM, Voss J, Graff C, et al. In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494). BMC Rheumatol. 2018;2:23.

5. Sornasse T, Sokolove J, McInnes I. Treatment with upadacitinib results in the normalization of key pathobiologic pathways in patients with rheumatoid arthritis: Biomarker results from the phase 3 selectnext and select-beyond studies [abstract no. THU0181]. Ann Rheum Dis. 2019;78(Suppl. 2):365–6.

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