Roles of Individual Disulfide Bridges in the Conformation and Activity of μ-Conotoxin GIIIA, a Peptide Blocker of Muscle Sodium Channels

Author:

Sato Kazuki,Yamaguchi Yoko,Ishida Yukisato

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Molecular Medicine,Biochemistry,Bioengineering,Analytical Chemistry

Reference30 articles.

1. Becker S, Prusak-Sochaczewski E, Zamponi G, Beck-Sickinger AG, Gordon RD, French RJ (1992) Action of derivatives of μ-conotoxin GIIIA on sodium channels. Single amino acid substitution in the toxin separately affect association and dissociation rates. Biochemistry 31:8229–8238

2. Catterall WA (1988) Structure and function of voltage-sensitive ion channels. Science 242:50–61

3. Chahine M, Chen L-Q, Fotouchi N, Walsky R, Fry D, Santarelli V, Horn R, Kallen RG (1995) Characterizing the μ-conotoxin binding site on voltage-sensitive sodium channels with toxin analogs and channel mutations. Recept Channels 3:161–174

4. Chang NS, French RJ, Lipkind GM, Fozzard HA, Dudley S Jr (1998) Predominant interactions between μ-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis. Biochemistry 37:4407–4419

5. Cruz LJ, Gray WR, Olivera BM, Zeikus RD, Kerr L, Yoshikami D, Moczydlowski E (1985) Conus geographus toxins that discriminate between neuronal and muscle sodium channels. J Biol Chem 260:9280–9288

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