The Host Defence Peptide LL-37 is Susceptible to Proteolytic Degradation by Wound Fluid Isolated from Foot Ulcers of Diabetic Patients-Reference-Cited by-同舟云学术

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The Host Defence Peptide LL-37 is Susceptible to Proteolytic Degradation by Wound Fluid Isolated from Foot Ulcers of Diabetic Patients

Published:2014-05-17 Issue:4 Volume:20 Page:457-464
ISSN:1573-3149
Container-title:International Journal of Peptide Research and Therapeutics
language:en
Short-container-title:Int J Pept Res Ther

Author:

McCrudden Maelíosa T. C.,McLean Denise T. F.,Zhou Mei,Shaw Julia,Linden Gerard J.,Irwin Chris R.,Lundy Fionnuala T.

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Molecular Medicine,Biochemistry,Bioengineering,Analytical Chemistry

Link

http://link.springer.com/content/pdf/10.1007/s10989-014-9410-3.pdf

Reference42 articles.

1. Agerberth B, Charo J, Werr J, Olsson B, Idali F, Lindbom L, Kiessling R, Jörnvall H, Wigzell H, Gudmundsson GH (2000) The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 96:3086–3093

2. Braff MH, Hawkins MA, Di Nardo A, Lopez-Garcia B, Howell MD, Wong C, Lin K, Streib JE, Dorschner R, Leung DY, Gallo RL (2005) Structure-function relationships among human cathelicidin peptides: disassociation of antimicrobial properties from host immunomodulatory activities. J Immunol 174:4271–4278

3. Brogden NK, Mehalick L, Fischer CL, Wertz PW, Brogden KA (2012) The emerging role of peptides and lipids as antimicrobial epidermal barriers and modulators of local inflammation. Skin Pharmacol Physiol 25:167–181

4. Carretero M, Escámez MJ, García M, Duarte B, Holguín A, Retamosa L, Jorcano JL, Río MD, Larcher F (2008) In vitro and in vivo wound healing-promoting activities of human cathelicidin LL-37. J Invest Dermatol 128:223–236

5. Chen SM, Ward SI, Olutoye OO, Diegelmann RF, Kelman Cohen I (1997) Ability of chronic wound fluids to degrade peptide growth factors is associated with increased levels of elastase activity and diminished levels of proteinase inhibitors. Wound Repair Regen 5(1):23–32

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