Structural and Molecular Interaction Studies on Familial Hypercholesterolemia Causative PCSK9 Functional Domain Mutations Reveals Binding Affinity Alterations with LDLR-Reference-Cited by-同舟云学术

Structural and Molecular Interaction Studies on Familial Hypercholesterolemia Causative PCSK9 Functional Domain Mutations Reveals Binding Affinity Alterations with LDLR

Published:2020-10-06 Issue:1 Volume:27 Page:719-733
ISSN:1573-3149
Container-title:International Journal of Peptide Research and Therapeutics
language:en
Short-container-title:Int J Pept Res Ther

Author:

Awan Zuhier Ahmed,Bahattab Rawabi,Kutbi Hussam Ibrahim,Noor Ahmad Omar Jamal,Al-Nasser Marzog S.,Shaik Noor Ahmad,Banaganapalli Babajan^ORCID

Funder

This project was funded by the Deanship of Scientific Research (DSR) at King Abdulaziz University

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Molecular Medicine,Biochemistry,Bioengineering,Analytical Chemistry

Link

https://link.springer.com/content/pdf/10.1007/s10989-020-10121-8.pdf

Reference57 articles.

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3. Al-Abbasi FA, Mohammed K, Sadath S, Banaganapalli B, Nasser K, Shaik NA (2018) Computational protein phenotype characterization of IL10RA mutations causative to early onset inflammatory bowel disease (IBD). Front Genet 9:146. https://doi.org/10.3389/fgene.2018.00146

4. Alnouri F et al (2018) Novel combined variants of LDLR and LDLRAP1 genes causing severe familial hypercholesterolemia. Atherosclerosis 277:425–433. https://doi.org/10.1016/j.atherosclerosis.2018.06.878

5. Anderson ED, Molloy SS, Jean F, Fei H, Shimamura S, Thomas G (2002) The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation. J Biol Chem 277:12879–12890. https://doi.org/10.1074/jbc.M108740200

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