Synthesis, Stability and Direct Antiproliferative Effect of New Cysteine Modified GnRH Analogs

Author:

Li SongtaoORCID,Zhao Hongling,Wang Ruxing,Wang Jianping,Mao Xiaoxia,Hao Ting,Chang Xiaomin,Zhao Enhong,Yin Zhifeng,Deng Shuhua,Yang Yaqi,Wang Huina

Funder

The Scientific Research Projects in Colleges and Universities of Hebei Province

Natural Science Foundation of Hebei Province

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Molecular Medicine,Biochemistry,Bioengineering,Analytical Chemistry

Reference32 articles.

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2. Chatzaki E, Bax CM, Eidne KA, Anderson L, Grudzinskas JG, Gallagher CJ (1996) The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor. Cancer Res 56(9):2059–2065

3. Dai T, Yin ZF, Zhao HL, Gao Y, Li YH, Li ST, Wang LY (2014) Synthesis of buserelin. Chin J New Drugs 23(15):1806–1810

4. Eidne KA, Flanagan CA, Millar RP (1985) Gonadotropin-releasing hormone binding sites in human breast carcinoma. Science 229(4717):989–991

5. Emons G, Ortmann O, Becker M, Irmer G, Springer B, Laun R (1993) High affinity binding and direct antiproliferative effects of LHRH analogues in human ovarian cancer cell lines. Cancer Res 53(22):5439–5446

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