Signal Peptide Optimization to Prevent N-terminal Truncation of Glucagon Like Peptide-1/IgG-Fc Fusion Protein
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Molecular Medicine,Biochemistry,Bioengineering,Analytical Chemistry
Link
https://link.springer.com/content/pdf/10.1007/s10989-020-10112-9.pdf
Reference17 articles.
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2. Barrington P, Chien JY, Tibaldi F, Showalter HD, Schneck K, Ellis B (2011) LY2189265, a long-acting glucagon-like peptide-1 analogue, showed a dose-dependent effect on insulin secretion in healthy subjects. Diab Obes Metab 13:434–438. https://doi.org/10.1111/j.1463-1326.2011.01365.x
3. Buse JB, Wexler DJ, Tsapas A, Rossing P, Mingrone G, Mathieu C, D’Alessio DA, Davies MJ (2019) Update to: management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European association for the study of diabetes (EASD). Diab Care. https://doi.org/10.2337/dci19-0066
4. Campbell JE, Drucker DJ (2013) Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab 17:819–837. https://doi.org/10.1016/j.cmet.2013.04.008
5. Deacon CF, Knudsen LB, Madsen K, Wiberg FC, Jacoben O, Holst JJ (1998) Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity. Diabeteologia 41:271–278. https://doi.org/10.1007/s001250050903
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