Antipsychotic phenothiazine drugs bind to KRAS in vitro-Reference-Cited by-同舟云学术

Antipsychotic phenothiazine drugs bind to KRAS in vitro

Published:2021-06-26 Issue:6-7 Volume:75 Page:233-244
ISSN:0925-2738
Container-title:Journal of Biomolecular NMR
language:en
Short-container-title:J Biomol NMR

Author:

Wang Xu,Gorfe Alemayehu A.,Putkey John A.^ORCID

Funder

Cancer Prevention and Research Institute of Texas

Publisher

Springer Science and Business Media LLC

Subject

Spectroscopy,Biochemistry

Link

https://link.springer.com/content/pdf/10.1007/s10858-021-00371-z.pdf

Reference47 articles.

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2. Araki M et al (2011) Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers. J Biol Chem 286:39644–39653

3. Attwood D, Florence AT, Gillan JM (1974) Micellar properties of drugs: properties of micellar aggregates of phenothiazines and their aqueous solutions. J Pharm Sci 63:988–993

4. Azuine MA et al (2004) Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-O-tetradecanoylphorbol-13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models. Pharmacol Res 49:161–169

5. Baciu-Atudosie L et al (2012) Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors. Bioorg Med Chem Lett 22:6896–6902

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