NMR-based fragment screening and lead discovery accelerated by principal component analysis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Spectroscopy,Biochemistry
Link
http://link.springer.com/content/pdf/10.1007/s10858-019-00279-9.pdf
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2. Fielding L (2007) NMR methods for the determination of protein-ligand dissociation constants. Prog Nucl Magn Reson Spectrosc 51:219–242
3. Hajduk PJ, Augeri DJ, Mack J, Mendoza R, Yang J, Betz SF, Fesik SW (2000) NMR-based screening of proteins containing 13C-labeled methyl groups. J Am Chem Soc 122:7898–7904
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5. Kranz JK, Schalk-Hihi C (2011) Protein thermal shifts to identify low molecular weight fragments. Methods Enzymol 493:277–298
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