Author:
Chaari Lotfi,Golubnitschaja Olga
Abstract
AbstractCovid-19 is neither the first nor the last viral epidemic which societies around the world are, were and will be affected by. Which lessons should be taken from the current pandemic situation? The Covid-19 disease is still not well characterised, and many research teams all over the world are working on prediction of the epidemic scenario, protective measures to populations and sub-populations, therapeutic and vaccination issues, amongst others. Contextually, countries with currently low numbers of Covid-19-infected individuals such as Tunisia are intended to take lessons from those countries which already reached the exponential phase of the infection distribution as well as from those which have the exponential phase behind them and record a minor number of new cases such as China. To this end, in Tunisia, the pandemic wave has started with a significant delay compared with Europe, the main economic partner of the country. In this paper, we do analyse the current pandemic situation in this country by studying the infection evolution and considering potential protective strategies to prevent a pandemic scenario. The model is predictive based on a large number of undetected Covid-19 cases that is particularly true for some country regions such as Sfax. Infection distribution and mortality rate analysis demonstrate a highly heterogeneous picture over the country. Qualitative and quantitative comparative analysis leads to a conclusion that the reliable “real-time” monitoring based on the randomised laboratory tests is the optimal predictive strategy to create the most effective evidence-based preventive measures. In contrast, lack of tests may lead to incorrect political decisions causing either unnecessary over-protection of the population that is risky for a long-term economic recession, or under-protection of the population leading to a post-containment pandemic rebound. Recommendations are provided in the context of advanced predictive, preventive and personalised (3P) medical approach.
Funder
Universitätsklinikum Bonn
Publisher
Springer Science and Business Media LLC
Subject
Biochemistry, medical,Health Policy,Drug Discovery
Reference12 articles.
1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. New England J Med. 2020;382(8):727–33.
2. Chih-Cheng L, Tzu-Ping S, Wen-Chien K, Hung-Jen T, Po-Ren H. Severe acute respiratory syndrome coronavirus 2 (sars-cov-2) and coronavirus disease-2019 (covid-19): the epidemic and the challenges. Int J Antimicrob Agents. 2020;55(3):1–9.
3. Gautret P, Lagier J C, Parola P, Thuan H V, Meddeb L, Sevestre J, Mailhe M, Doudier B, Aubry C, Amrane S, Seng P, Hocquart M, Finance J, Vieira V E, Dupont H T, Honor S, Stein A, Million M, Colson P, Scola B L, Veit V, Jacquier A, Drancourt J C D M, Fournier P E, Rolain J M, Brouqui P, Raoult D. Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: an observational study. In: Méditerranée Infection. 2020. https://www.mediterranee-infection.com/wpcontent/uploads/2020/03/COVID-IHU-2-1.pdf. Accessed March 27 2020.
4. Kim SJS, Shin DH, Kim MS. Inhibition of sars-cov 3cl protease by flavonoids. J Enzyme Inhib Med Chem. 2020;35(3):145–51.
5. A Study of a Candidate COVID-19 Vaccine (COV001). In: U. S. National Library of Medicine. 2020. https://www.clinicaltrials.gov/ct2/show/study/NCT04324606. Accessed March 27, 2020.
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