The effect of over-expression of rate limiting enzymes on the yield of artemisinin in Artemisia annua

Author:

Alam Pravej,Kamaluddin ,Sharaf-Eldin Mahmoud A.,Elkholy Shereen F.,Abdin Malik Zainul

Publisher

Springer Science and Business Media LLC

Subject

General Earth and Planetary Sciences,General Agricultural and Biological Sciences,General Environmental Science

Reference25 articles.

1. Abdin MZ, Alam P (2015) Genetic engineering of artemisinin biosynthesis: prospects to improve its concentration. Act Physiol Plant. doi: 10.1007/s11738-015-1771-5

2. Abdin MZ, Israr M, Rehman RU, Jain SK (2003) Artemisinin, a novel antimalarial drug: biochemical and molecular approaches for enhanced production. Planta Med 69:289–293

3. Akhila A, Kumkum R, Thakur RS (1990) Biosynthesis of artemisinic acid in Artemisia annua. Phytochemistry 29:2129–2132

4. Alam P, Abdin MZ (2011) Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content. Plant Cell Rep 10:1919–1928

5. Alam P, Kamaluddin Khan MA, Mohammad A, Khan R, Abdin MZ (2014) Enhanced artemisinin accumulation and metabolic profiling of transgenic Artemisia annua L. plants over-expressing by rate limiting enzymes from isoprenoid pathway. J Plant Interact. doi: 10.1080/17429145.2014.893030

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