Nonlinear ultrasound in liquid containing multiple coated microbubbles: effect of buckling and rupture of viscoelastic shell on ultrasound propagation

Author:

Nguyen Quoc NamORCID,Kanagawa TetsuyaORCID

Abstract

AbstractWith promising applications in medical diagnosis and therapy, the behavior of shell-encapsula-ted ultrasound contrast agents (UCAs) has attracted considerable attention. Currently, second-generation contrast agents stabilized by a phospholipid membrane are widely used and studies have focused on the dynamics of single phospholipid shell-encapsulated microbubbles. To improve the safety and the efficiency of the methods using the propagation or targeted ultrasound, a better understanding of the propagation of ultrasound in liquids containing multiple encapsulated microbubbles is required. By incorporating the Marmottant–Gompertz model into the multiple scale analysis of two-phase model, this study derived a Korteweg–de Vries–Burgers equation as a weakly nonlinear wave equation for one-dimensional ultrasound in bubbly liquids. It was found that the wave propagation characteristics changed with the initial surface tension, highlighting two notable features of the phospholipid shell: buckling and rupture. These results may provide insights into the suitable state of microbubbles, and better control of ultrasound for medical applications, particularly those that require high precision.

Funder

Japan Society for the Promotion of Science London

New Energy and Industrial Technology Development Organization

Ono Charitable Trust for Acoustics

Publisher

Springer Science and Business Media LLC

Subject

Electrical and Electronic Engineering,Applied Mathematics,Mechanical Engineering,Ocean Engineering,Aerospace Engineering,Control and Systems Engineering

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