Systemic overexpression of antizyme 1 in mouse reduces ornithine decarboxylase activity without major changes in tissue polyamine homeostasis

Author:

Pietilä Marko,Dhungana Hiramani,Uimari Anne,Sironen Reijo,Alhonen Leena

Publisher

Springer Science and Business Media LLC

Subject

Agronomy and Crop Science,Genetics,Animal Science and Zoology,Biotechnology

Reference33 articles.

1. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (2007) Current protocols in molecular biology. Wiley, Hoboken

2. Bailey HH, Kim K, Verma AK et al (2010) A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of α-difluoromethylornithine in subjects with previous history of skin cancer. Cancer Prev Res 3:35–47

3. Casero R Jr, Frydman B, Stewart TM, Woster PM (2005) Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues. Proc West Pharmacol Soc 48:24–30

4. Feith DJ, Shantz LM, Pegg AE (2001) Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis. Cancer Res 61:6073–6081

5. Fong LYY, Feith DJ, Pegg AE (2003) Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. Cancer Res 63:3945–3954

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